Aims and background: Globally, trauma is the leading cause of death in individuals under 45 years of age. However, there is limited research on this topic in Chile and no nationwide studies on polytrauma. This underscores the need for further research. The aim is to analyze the temporal evolution and potential geographical variability of mortality attributed to polytrauma in Chile over the last 25 years. Materials and methods: This was a cross-sectional, observational, quantitative study of routine Chilean records, which are mandatorily reported and publicly anonymized, available on the website of the Department of Health Statistics and Information (DEIS). All records under code T00-T07 [International Statistical Classification of Diseases and Related Health Problems (ICD-10)] were included in the analysis (nonprobabilistic convenience sampling). Variables studied were gender, age, region, external cause, date, and place of death. Specific mortality rates (SMR) and age-adjusted rates were calculated with statistical significance (p < 0.05) using Statistical Software for Data Science (STATA)—16. Ethical approval was not required. Results: A total of 38,955 death records were analyzed. The SMR for the period was 8.45 per 100,000 inhabitants, peaking in 2008 at 10.03 per 100,000. The SMR for men was 13.62 per 100,000, and for women, it was 3.47 per 100,000; in both cases, the rates were highest between the ages of 20 and 44. Relative risk: 3.92 (p < 0.01). The O'Higgins region had the highest SMR at 13.67 per 100,000, while the Magallanes region had the lowest at 5.35 per 100,000. The most common cause was “pedestrian injured in transport accident” (32.73%). Most deaths occurred on public roads, on Mondays, and during the month of February. Conclusion: Deaths attributed to polytrauma in the Chilean population are distributed differently across various variables. A rising trend has been observed since 2020. Further studies are necessary to delve into the reasons for geographical variability and the mechanisms of trauma.