Aims and background: Interpersonal violence poses significant health and social challenges. This study examines trends in interpersonal physical violence in Chile from 2003 to 2022. Materials and methods: Observational cross-sectional study. Data obtained from the Servicio Médico Legal and Departamento de Estadísticas e Información de Salud. Variables analyzed included sex, age, region, type of aggression, and injury. Statistical analysis, using Stata 17, evaluated trends, mortality, and hospital discharge rates (HDR). Ethical committee approval was unnecessary. Results: Between 2003 and 2022, Chile recorded 75,129 hospital admissions and 14,519 deaths related to physical assaults. While HDR due to assaults (HDRA) showed a decline, a rising trend was seen post-2019. The highest HDRA rates were in the northern area of Chile. Mortality rates decreased overtime and varied by region. Men had higher hospital admissions (91.36%), HDRAs, and mortality, revealing a gender gap. Variations were also noted by age, types of aggression, and trauma. Sharp object assaults were most prevalent, but firearms and blunt objects increased. Conclusion: Findings suggest a complex landscape of interpersonal physical violence in Chile, with significant regional, gender, and age disparities. While violence incidence is decreasing, severity could be rising, reflected by lethality rates. Gender inequalities in exposure and risk of violence are evident. Changes in aggression types and injuries impact health services readiness and response. Clinical significance: This study provides information to guide effective intervention policies in Chile, considering trends, geographical differences, gender inequalities, and changes in types of aggression and injuries.