Aim and background: Trauma registries have been developed to track patient characteristics and outcomes to develop clinical decision tools. However, maintenance of trauma registries can be time-intensive and expensive, particularly in resource-limited areas. This qualitative study aims to assess the feasibility of implementing a real-time electronic data capture system and clinical practice guideline (CPG) platform, T6 Health Systems Mobile Application (T6), in the Calixto-Garcia Hospital's (CGH) emergency and trauma department in Havana, Cuba. Materials and methods: Our qualitative study utilized six 8-hour focus groups with nine participants each over 4 months to determine which aspects of T6 would be best adapted for CGH and to identify challenges to its use. Focus group participants were chosen via convenience sampling, and a grounded theory approach for thematic analysis was used to identify common themes. Transcripts were reviewed by two independent reviewers. Results: Four major priorities for the implementation of T6 at CGH were identified: prehospital-hospital communication, T6 customization, training on trauma scoring systems, and incorporation of CPG for education and clinical decision-making. Challenges to the integration of this system include language barriers, unreliable internet connectivity, and prohibitive costs. Conclusion: Our study reveals the complexities of integrating an electronic trauma registry and guidelines in a resource-limited setting. Implementation of T6, although challenging, highlights the potential to enhance patient outcomes, interdisciplinary communication, and hospital efficiency. Clinical significance: This study demonstrated facilitators and barriers to implementing a real-time electronic data capture system and CPG platform for trauma patients in a major trauma center in Cuba.