Introduction: The approach of penetrating neck trauma has evolved over time, from considering the expectant management in the 1950s, going through exploratory cervicotomy in the 1960s and 1970s, and later with the advanced technology to the selective management by zones or “no zone approach” (according to the symptomatology of the patient). Design: This is a descriptive cross-sectional observational study in 51 patients aged 18 years or older with penetrating neck trauma. Results: The median age was 29 years, and the majority of them were male (92.3%). Left laterality and zone 2 were the most common locations of the injury in 48.1 and 49% respectively. Stab wounds were the main cause of trauma (86.27%); 80.39% of the patients underwent neck angiography; 19.02% (n = 10) of the patients showed any hard signs of aerodigestive injury and were taken to surgery rooms. Within the intraoperative findings, 7 patients had vascular injury and 1 had a hypopharyngeal lesion. There were no airway injuries; 53% of the patients had associated injuries within which the upper limb, thorax, and face were the most frequent. Conclusions: Penetrating neck trauma is common in our environment; most patients come hemodynamically stable, allowing a selective evaluation to be made according to the affected area or symptoms. The most frequent surgical finding was venous vascular lesion.